Atalanta have new signing Ederson supporting Luis Muriel and Duvan Zapata for the trip to Newcastle United, but Jose Luis Palomino is suspended after failing a doping test.
It kicks off at St James’ Park at 19.45 UK time (18.45 GMT).
La Dea are forced to do without Palomino, who is ready to lodge an appeal after failing a surprise pre-season doping test for the presence of a metabolite from an anabolic steroid.
Both Palomino and Atalanta maintain his innocence and are waiting for the counter-analysis of the sample.
Meanwhile, former Salernitana man Ederson starts behind the strikers, although Luis Muriel is still linked with a transfer this summer.
It gives an opportunity for young Italy international Giorgio Scalvini to test himself out in defence.
Newcastle United: Pope; Trippier, Schar, Burn, Targett; S Longstaff, Anderson, Almiron, Murphy, Fraser; Wood
Newcastle bench: Gillespie, M Longstaff, De Bolle, Munoz, Bondswell, Stephenson, Turner-Cooke, A Murphy, Miley
Atalanta: Sportiello; Toloi, Scalvini, Okoli; Zortea, De Roon, Koopmeiners, Maehle; Ederson; Muriel, Zapata
Atalanta bench: Musso, Rossi, Boga, Freuler, Lammers, Malinovskyi, Djimsiti, Ruggeri, Hateboer, Bernasconi, Pasalic